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Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 548-553 doi: 10.1007/s11684-017-0597-5
Keywords: PBMC HBV cccDNA HBV rcDNA HBV intrauterine transmission
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 158-165 doi: 10.1007/s11684-014-0340-4
Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.
Keywords: antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission pregnancy prevention
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2, Pages 178-185 doi: 10.1007/s11705-016-1558-2
Keywords: RNA catalysis RNA structure catalytic mechanism
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 129-134 doi: 10.1007/s11684-014-0339-x
Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that iswith assumed host responses to HBV infection.and reinfection, and such cycles prolong the chronic HBV infection course.
Keywords: hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion
A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests Article
Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si
Engineering 2024, Volume 32, Issue 1, Pages 174-185 doi: 10.1016/j.eng.2023.06.013
Chronic hepatitis B virus (HBV) infection, which threatens global publicExaminations for liver diseases related to chronic HBV infection—including laboratory tests, ultrasoundsestablish an economical and effective diagnosis method in order to streamline the medical process for HBV-related
Keywords: HBV-related diseases Functional resilience Improve medical resource utilization Critical states Network
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 21-29 doi: 10.1007/s11684-020-0744-2
Keywords: hepatitis B virus mother-to-child transmission progress challenge
Anti RNA Viruses Related Biomaterials
Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo
Strategic Study of CAE 2003, Volume 5, Issue 7, Pages 17-23
The structure, reproduction, replication and transcription of RNA viruses were introduced.Antivirus strategies including design of anti - SARS drugs, RNA interference, DNA vaccine delivery systemThese examples imply the interactions of RNA viruses with proteins, DNA, and polysaccharides.
Keywords: Anti-RNA viruses protein DNA polysaccharide biomaterials
RNA-Based Biocontrols—A New Paradigm in Crop Protection Review
Matthew Bramlett, Geert Plaetinck, Peter Maienfisch
Engineering 2020, Volume 6, Issue 5, Pages 522-527 doi: 10.1016/j.eng.2019.09.008
Keywords: RNA-based biocontrols RNA interference (RNAi) Colorado potato beetle (CPB) Corn rootworm (CRW) Soy
Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression Article
Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo
Engineering 2023, Volume 21, Issue 2, Pages 187-193 doi: 10.1016/j.eng.2021.12.007
Osteosarcoma (OS) is a malignant mesenchymal tissue tumor known to occur in children and adolescents, and pulmonary metastasis often leads to death in these patients. The mechanism underlying OS progression remains unclear. Therefore, identifying new therapeutic targets and treatment modalities for OS is urgently needed. Abnormally expressed non-coding circular RNAs (circRNAs) are crucial for the occurrence and development of OS. The purpose of this study was to explore the expression and role of a novel circRNA circ_000203 in OS and elucidate the underlying mechanism. circ_000203 was demonstrated highly expressed in OS cell lines and tissues, and circ_000203 knockdown significantly inhibited OS progression in vitro and in vivo. Furthermore, we found that circ_000203 is a sponge of miR-26b-5p, an upstream regulator of bone morphogenetic protein receptor 2 (BMPR2). Thus, the overexpression of BMPR2 could reduce the inhibitory effect on OS progression. This indicates that knockdown of circ_000203 suppresses OS progression through microRNA (miRNA)-mediated BMPR2 downregulation. Our findings provide important insights for understanding the occurrence and development of OS.
Keywords: Non-coding RNA Osteosarcoma CircRNA Molecular mechanism Knockdown
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 166-170 doi: 10.1007/s11684-008-0030-1
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 308-311 doi: 10.1007/s11684-007-0059-6
Keywords: CKD non-dialysis valuable detection chronic
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 330-343 doi: 10.1007/s11684-017-0557-0
Keywords: long noncoding RNA CRNDE alternative splicing
Direct acting antiviral-induced dynamic reduction of serum
Tung Huynh, Ke-Qin Hu
Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 658-666 doi: 10.1007/s11684-019-0707-7
Keywords: chronic hepatitis C α fetoprotein direct acting antiviral treatment cirrhosis
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
Title Author Date Type Operation
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang
Journal Article
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Journal Article
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
Journal Article
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Journal Article
A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests
Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si
Journal Article
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Journal Article
RNA-Based Biocontrols—A New Paradigm in Crop Protection
Matthew Bramlett, Geert Plaetinck, Peter Maienfisch
Journal Article
Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression
Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo
Journal Article
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
Journal Article
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
Journal Article
Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
Journal Article